Acidity is a function of the concentration of hydrogen ions [H+] and is measured as pH. Environments with pH values below 7.0 are considered acidic, whereas those with pH values above 7.0 are considered basic. Extreme pH affects the structure of all macromolecules.The component most sensitive to pH in the cell is its workhorse, the protein. Moderate changes in pH modify the ionization of amino-acid functional groups and disrupt hydrogen bonding, which, in turn, promotes changes in the folding of the molecule, promoting denaturation and destroying activity.Most harmful pathogens thrive in a near nutral environment between 6-7 and are eradicated in acidic pH yet the lower the pH the higher the ORP (Oxidation Reduction Potential). ORP (measured in mV) is the dominant factor that does not enable the pathogens to develop resistance and multiply.Sterisent’s ability to control and maintain exact pH and ORP levels, has a major significance on the efficacy of its generated HOCl as a disinfectant. For decades Chlorine has been used as the preferred disinfectant yet its toxicity and odor repelled both patients and care providers. HOCl is the most potent of chlorine compounds regarding bacterial attack, has no toxic effects on humans, animals and the environment and the majority of users do not detect any odor.